Development of Mouse Embryos after Immunoneutralization of Mitogenic Growth Factors Mimics that of Cloned Embryos – part 2

However, the extent to which expression of mitogenic growth factors is essential for normal development of preimplantation embryos is not known. Previously, we found that expression levels of epidermal growth factor (EGF), transforming growth factor a (TGFa), and their cognate receptor, epidermal growth factor receptor (EGFR), were reduced significantly in preimplantation cloned mouse embryos. Continue reading